No synergism between bis(propyl)-cognitin and rasagiline on protecting dopaminergic neurons in Parkinson's disease mice.
Cheng-You ZhengBao-Jian GuoWei CaiWei CuiShing-Hung MakYu-Qiang WangSimon Ming-Yuen LeeYi-Fan HanZai-Jun ZhangPublished in: Neural regeneration research (2016)
Rasagiline, a monoamine oxidase-B inhibitor, and bis(propyl)-cognitin (B3C), a novel dimer are reported to be neuroprotective. Herein, the synergistical neuroprotection produced by rasagiline and B3C was investigated in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice of Parkinsonism. By using neurobehavioural tests, high-performance liquid chromatography and western blot assay, we showed that B3C at 0.3 mg/kg, rasagiline at 0.02 mg/kg, as well as co-treatment with B3C and rasagiline prevented MPTP-induced behavioural abnormities, increased the concentrations of dopamine and its metabolites in the striatum, and up-regulated the expression of tyrosine hydroxylase in the substantia nigra. However, the neuroprotective effects of co-treatment were not significantly improved when compared with those of B3C or rasagiline alone. Collectively, we have demonstrated that B3C at 0.3 mg/kg and rasagline at 0.02 mg/kg could not produce synergistic neuroprotective effects.
Keyphrases
- high performance liquid chromatography
- high glucose
- diabetic rats
- drug induced
- cerebral ischemia
- poor prognosis
- south africa
- ionic liquid
- simultaneous determination
- transcription factor
- spinal cord
- type diabetes
- high throughput
- brain injury
- oxidative stress
- combination therapy
- parkinson disease
- subarachnoid hemorrhage
- binding protein
- long non coding rna
- atomic force microscopy
- deep brain stimulation
- wild type
- liquid chromatography