Testing of microencapsulated porcine hepatocytes in a new model of fulminant liver failure in baboons.

Zurab MachaidzeHeidi YehLingling WeiChristian SchuetzMichele CarvelloAntonino SgroiRex N SmithHenk-Jan SchuurmanDavid H SachsPhilippe MorelJames F MarkmannLéo H Bühler

Published in: Xenotransplantation (2017)

The results indicate that microencapsulated porcine hepatocytes provide temporary liver function support in baboons with fulminant liver failure. These data support development of this cell therapy product toward clinical trials in patients with acute liver failure.

Keyphrases

liver failure
cell therapy
hepatitis b virus
clinical trial
stem cells
mesenchymal stem cells
liver injury
electronic health record
randomized controlled trial
bone marrow
phase ii