Two new eudesmane-type sesquiterpene derivatives from Lecokia cretica (Lam.) DC.

Two new sesquiterpene glucosides, 1 α ,6 β ,9 β -trihydroxy-eudesm-4(15)-en-1,6- O - β -diglucopyranoside ( 1 ) and 1 α ,6 β ,9 β -trihydroxy-eudesm-3-en-1,6- O - β -diglucopyranoside ( 2 ) were obtained along with the 1α,6 β ,9 β -trihydroxy-5,10-bis-epi-eudesm-3-en-6- O - β -D-glucopyranoside (3) , chlorogenic acid (4) , luteolin 7- O -rutinoside (5) and luteolin 7- O - glucoside (6) from the whole plant parts of Lecokia cretica . Their structures were determined on the basis of 1 D, 2 D NMR and HRMS analyses. The in vitro cytotoxic activity of compounds 1-3 against human lung cancer cells (A549) and normal human lung cells (BEAS-2B) was determined using the MTT colorimetric assay. All the tested eudesmane derivatives were found to be inactive.