Folate receptor alpha in ovarian cancer tissue and patient serum is associated with disease burden and treatment outcomes.
Heather J BaxJitesh ChauhanChara StavrakaAida SantaolallaGabriel OsbornAtousa KhiabanyMelanie GranditsJacobo López-AbenteLais C G F PalharesCharleen Chan Wah HakAlexandra RobinsonAmy PopeNatalie WoodmanCristina Naceur-LombardelliSadek MalasJack E M CoumbeMano NakamuraRoman LaddachSilvia MeleSilvia CrescioliAnna M BlackSara LombardiSilvana CanevariMariangela FiginiAhmad SayasnehSophia TsokaKevin FitzGeraldCheryl GillettSarah E PinderMieke Van HemelrijckRebecca S KristeleitSharmistha GhoshAna MontesJames SpicerSophia N KaragiannisDebra H JosephsPublished in: British journal of cancer (2022)
sFRα may present a non-invasive marker for tumour FRα expression, with the potential for monitoring patient response to treatment. Larger, prospective studies should evaluate FRα for assessing disease burden and response to systemic treatments.