Gene Expression Profile Signature of Aggressive Waldenström Macroglobulinemia with Chromosome 6q Deletion.
Naohiro SekiguchiJunko NomotoAkihisa NagataMasahiro KiyotaIchiro FukudaKazuaki YamadaNaoki TakezakoYukio KobayashiPublished in: BioMed research international (2018)
The present study suggested that the BCR signaling pathway and IL21R expression are activated in WM with 6q del. Moreover, FOXP1 and CBLB appear to act as positive regulators of the BCR signaling pathway. These findings might be attributed to the aggressiveness of the WM with 6q del expression signature.