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Enantioselective Intramolecular Copper-Catalyzed Borylacylation.

Andrew WhyteKatherine I BurtonJingli ZhangMark Lautens
Published in: Angewandte Chemie (International ed. in English) (2018)
An enantioselective copper-catalyzed intramolecular borylacylation is reported. The reaction proceeds through an initial enantioselective borylcupration of the styrene, followed by a nucleophilic attack on the tethered carbamoyl chloride. The products, chiral borylated 3,3-disubstituted oxindoles, were generated in excellent yields and enantioselectivities. The versatile carbon-boron bond provides a platform for a wide array of diversification.
Keyphrases
  • high throughput
  • energy transfer
  • high resolution
  • ionic liquid
  • capillary electrophoresis
  • quantum dots