Effect of clinical response to active drugs and placebo on antipsychotics and mood stabilizers relative efficacy for bipolar depression and mania: A meta-regression analysis.

Francesco Bartoli Massimo Clerici Carmen Di Brita Ilaria Riboldi Cristina Crocamo Giuseppe Carrà

Published in: Journal of psychopharmacology (Oxford, England) (2018)

Despite several limitations, our unexpected findings showed that antipsychotics / mood stabilisers relative efficacy for bipolar depression seems unrelated to active drugs response rates, depending only on clinical response to placebo. Future research should explore strategies to reduce placebo-related issues in randomised, placebo-controlled trials for bipolar depression.

Keyphrases

bipolar disorder
placebo controlled
double blind
sleep quality
depressive symptoms
phase iii
clinical trial
study protocol
open label
phase ii
randomized controlled trial
radiation therapy
physical activity
data analysis
locally advanced