Remifentanil promotes osteoblastogenesis by upregulating Runx2/osterix expression in preosteoblastic C2C12 cells.

Ji-Young Yoon Tae-Sung Kim Ji-Hye Ahn Ji-Uk Yoon Hyung Joon Kim Eun-Jung Kim

Published in: Journal of dental anesthesia and pain medicine (2019)

We demonstrated that remifentanil increased osteoblast differentiation in vitro by upregulation of Runx2 and osterix expression. Therefore, remifentanil has the potential for assisting with bone formation and bone healing.

Keyphrases

poor prognosis
transcription factor
induced apoptosis
long non coding rna
cell cycle arrest
signaling pathway
binding protein
cell proliferation
cell death
body composition
soft tissue
human health
pi k akt
bone loss