Ascorbic acid alters cell fate commitment of human neural progenitors in a WNT/β-catenin/ROS signaling dependent manner.

Tareck RharassMargareta LantowAdam GbankotoDieter G WeissDaniela PanákováStéphanie Lucas

Published in: Journal of biomedical science (2017)

Our findings demonstrate that AA treatment elevates ROS metabolism in a non-lethal manner prior to the NPCs commitment to their neuronal fate. Such effect stimulates the redox-sensitive DVL2 activation and WNT/β-catenin signaling response that would enhance the ensuing neuronal cell differentiation.

Keyphrases

cell fate
cell proliferation
cell death
stem cells
dna damage
endothelial cells
reactive oxygen species
cerebral ischemia
epithelial mesenchymal transition
induced pluripotent stem cells
pluripotent stem cells
combination therapy