The functional and molecular roles of p75 neurotrophin receptor (p75 NTR ) in epilepsy.
Areej TurkistaniHayder M Al-KuraishyAli I Al-GareebAli K AlbuhadilyOmnya ElhussienyAmmar Al-FargaFaisal AqlanHebatallah M SaadGaber El-Saber BatihaPublished in: Journal of central nervous system disease (2024)
Epilepsy is a chronic neurological disorder manifested by recurring unprovoked seizures resulting from an imbalance in the inhibitory and excitatory neurotransmitters in the brain. The process of epileptogenesis involves a complex interplay between the reduction of inhibitory gamma-aminobutyric acid (GABA) and the enhancement of excitatory glutamate. Pro-BDNF/p75 NTR expression is augmented in both glial cells and neurons following epileptic seizures and status epileptics (SE). Over-expression of p75 NTR is linked with the pathogenesis of epilepsy, and augmentation of pro-BDNF/p75 NTR is implicated in the pathogenesis of epilepsy. However, the precise mechanistic function of p75 NTR in epilepsy has not been completely elucidated. Therefore, this review aimed to revise the mechanistic pathway of p75 NTR in epilepsy.
Keyphrases
- temporal lobe epilepsy
- poor prognosis
- induced apoptosis
- venous thromboembolism
- binding protein
- signaling pathway
- spinal cord
- cell death
- cell proliferation
- anti inflammatory
- cell cycle arrest
- long non coding rna
- brain injury
- oxidative stress
- subarachnoid hemorrhage
- neuropathic pain
- soft tissue
- cerebral ischemia
- resting state