Efficacy of topical cannabinoids in the management of pain: a systematic review and meta-analysis of animal studies.
Lukas D LindeCarey M OgryzloCassandra M CholesBrian E CairnsJohn L K KramerPublished in: Regional anesthesia and pain medicine (2022)
Preclinical animal studies provided low-quality evidence for peripherally administered cannabinoids to provide regional, antinociceptive effects. The scarcity of high-quality human studies underscores the need to translate preclinical evidence into well-controlled human trials.