A Review on the Crosstalk between Insulin and Wnt/β-Catenin Signalling for Bone Health.
Sok Kuan WongNur Vaizura MohamadPutri Ayu JayusmanNurul 'Izzah IbrahimPublished in: International journal of molecular sciences (2023)
A positive association between insulin resistance and osteoporosis has been widely established. However, crosstalk between the signalling molecules in insulin and Wingless (Wnt)/beta-(β-)catenin transduction cascades orchestrating bone homeostasis remains not well understood. The current review aims to collate the existing evidence, reporting (a) the expression of insulin signalling molecules involved in bone-related disorders and (b) the expression of Wnt/β-catenin signalling molecules involved in governing insulin homeostasis. The downstream effector molecule, glycogen synthase kinase-3 beta (GSK3β), has been identified to be a point of convergence linking the two signal transduction networks. This review highlights that GSK3β may be a drug target in the development of novel anabolic agents and the potential use of GSK3β inhibitors to treat bone-related disorders.
Keyphrases
- type diabetes
- bone mineral density
- cell proliferation
- glycemic control
- insulin resistance
- epithelial mesenchymal transition
- postmenopausal women
- signaling pathway
- pi k akt
- poor prognosis
- stem cells
- soft tissue
- bone loss
- bone regeneration
- healthcare
- body composition
- public health
- adipose tissue
- emergency department
- metabolic syndrome
- dendritic cells
- binding protein
- high fat diet
- risk assessment
- immune response
- long non coding rna
- polycystic ovary syndrome
- social media
- human health
- weight loss