Metabolic regulation of hepatic PNPLA3 expression and severity of liver fibrosis in patients with NASH.

Francesca Virginia BruschiMatteo TardelliMerima HeracThierry ClaudelMichael Trauner

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

Collectively, our observations uncover the diverse metabolic regulation of PNPLA3 among different hepatic cell populations and support its relation to fibrosis progression.

Keyphrases

liver fibrosis
poor prognosis
single cell
cell therapy
genetic diversity