Mineral trioxide aggregate affects cell viability and induces apoptosis of stem cells from human exfoliated deciduous teeth.

Chia-Ling TsaiMu-Chan KeYi-Hao ChenHsi-Kung KuoHun-Ju YuChueh-Tan ChenYa-Chi TsengPei-Chin ChuangPei-Chang Wu

Published in: BMC pharmacology & toxicology (2018)

This study shows that direct contact with 1 week post-set MTA significantly decreases the viability of SHEDs and induced cell apoptosis. The results suggest that there is a possible cytotoxic effect of pulp tissue when there is direct contact with MTA. Different responses would be expected due to the strong alkaline characteristics of fresh mixed MTA.

Keyphrases

endothelial cells
high glucose
cell proliferation
induced pluripotent stem cells
pluripotent stem cells
study protocol
oxidative stress
anaerobic digestion
stress induced
cone beam computed tomography