Augmented capacity for peripheral serotonin release in human obesity.

Richard L YoungAmanda L LumsdenAlyce M MartinGudrun SchoberNektaria PezosSony S ThazhathNicole J IsaacsNada CvijanovicEmily W L SunTongzhi WuChristopher K RaynerNam Q NguyenDayan de FontgallandPhilippa RabbittPaul HollingtonLuigi SposatoSteven L DueDavid A WattchowAlice P LiouV Margaret JacksonDamien J Keating

Published in: International journal of obesity (2005) (2018)

Human obesity is characterized by an increased capacity to produce and release 5-HT from the proximal small intestine, which is strongly linked to higher body mass, and glycemic control. Gut-derived 5-HT is likely to be an important driver of pathogenesis in human obesity and dysglycemia.

Keyphrases

endothelial cells
type diabetes
weight loss
insulin resistance
metabolic syndrome
glycemic control
induced pluripotent stem cells
pluripotent stem cells
weight gain
high fat diet induced
adipose tissue