A comprehensive review on miR-451: A promising cancer biomarker with therapeutic potential.
Monireh KhordadmehrFarinaz Jigari-AslHamed EzzatiRoya ShahbaziSanam SadreddiniSahar SafaeiBehzad BaradaranPublished in: Journal of cellular physiology (2019)
MicroRNAs (miRNAs) are proposed as a family of short noncoding molecules able to manage and control the expression of the gene targets at the posttranscriptional level. They contribute in several fundamental physiological mechanisms as well as a verity of human and animal diseases such as cancer progression. Among these tiny RNAs, miR-451 placed on chromosome 17 at 17q11.2 presents an essential role in many biological processes in health condition and also in pathogenesis of different diseases. Besides, it has been recently considered as a valuable biomarker for cancer detection, prognosis and treatment. Therefore, this review will provide the critical functions of miR-451 on biological mechanisms including cell cycle and proliferation, cell survival and apoptosis, differentiation and development as well as disease initiation and progression such as tumor formation, migration, invasion, and metastasis.
Keyphrases
- cell proliferation
- cell cycle
- papillary thyroid
- long non coding rna
- squamous cell
- long noncoding rna
- poor prognosis
- healthcare
- endothelial cells
- oxidative stress
- public health
- squamous cell carcinoma
- copy number
- mental health
- dna methylation
- gene expression
- young adults
- childhood cancer
- cell migration
- risk assessment
- health information
- transcription factor
- binding protein
- cell cycle arrest
- loop mediated isothermal amplification
- pi k akt
- label free