A target trial emulation comparing the antidepressant effectiveness of selective serotonin reuptake inhibitors (SSRIs) highlighting the importance of patent-related confounding by indication.

Christopher Rohde Fredrik Hieronymus Søren Dinesen Østergaard

Published in: Acta psychiatrica Scandinavica (2024)

Sertraline, citalopram, and escitalopram do not seem to have differential effectiveness in the treatment of depression. Taking potential patent-related, time varying, confounding by indication (via severity) into account is critical for pharmacoepidemiological studies, including those employing target trial emulation.

Keyphrases

randomized controlled trial
study protocol
major depressive disorder
systematic review
phase iii
clinical trial
phase ii
depressive symptoms
bipolar disorder
physical activity
climate change
placebo controlled