Isoliquiritin Ameliorates Ulcerative Colitis in Rats through Caspase 3/HMGB1/TLR4 Dependent Signaling Pathway.
Zhiwei MiaoMingjia GuFaisal RazaHajra ZafarJianyi HuangYuhang YangMuhammad SulaimanJing YanYi XuPublished in: Current gene therapy (2023)
Isoliquiritin could reduce intestinal inflammation and mucosal damage of TNBS-induced colitis in rats with a certain anti-UC effect. Meanwhile, isoliquiritin treatment also inhibited the expression of HMGB1, TLR4, and MyD88 in LPS-induced Caco-2 cells. These results indicated that isoliquiritin could ameliorate UC through the caspase-3/HMGB1/TLR4-dependent signaling pathway.
Keyphrases
- induced apoptosis
- inflammatory response
- signaling pathway
- lps induced
- toll like receptor
- oxidative stress
- ulcerative colitis
- endoplasmic reticulum stress
- pi k akt
- immune response
- cell death
- nuclear factor
- cell cycle arrest
- epithelial mesenchymal transition
- poor prognosis
- mouse model
- binding protein
- combination therapy
- replacement therapy