18F-C2Am: a targeted imaging agent for detecting tumor cell death in vivo using positron emission tomography.

Flaviu BulatFriederike HesseDe-En HuSusana RosConnor Willminton-HolmesBangwen XieBala AttiliDmitry SolovievFranklin AigbirhioFinian J LeeperKevin M Brindle André A Neves

Published in: EJNMMI research (2020)

The rapid clearance of 18F-C2Am from the blood pool and low kidney retention allowed the spatial distribution of cell death in a tumor to be imaged during the course of therapy, providing a rapid assessment of tumor treatment response. 18F-C2Am has the potential to be used in the clinic to assess early treatment response in tumors.

Keyphrases

cell death
positron emission tomography
computed tomography
primary care
stem cells
cell proliferation
mass spectrometry
loop mediated isothermal amplification
bone marrow
human health