Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936.
Una ClancyRatko RadakovicFergus DoubalMaria Del C Valdés HernándezSusana Muñoz ManiegaAdele M TaylorJanie CorleyFrancesca M ChappellTom C RussSimon R CoxMark E BastinIan J DearyJoanna M WardlawPublished in: International journal of geriatric psychiatry (2022)
Apathy independently associates with preceding longitudinal WMH progression, while depression, anxiety, and subjective memory complaints do not. Patients with apathy should be considered for enrolment to small vessel disease trials.