Coronary Artery Disease Risk of Familial Hypercholesterolemia Genetic Variants Independent of Clinically Observed Longitudinal Cholesterol Exposure.

Shoa L Clarke Catherine Tcheandjieu Austin T Hilliard Kyung Min Lee Julie A Lynch Kyong-Mi ChangDonald MillerJoshua W Knowles Christopher J O'Donnell Philip S Tsao Daniel James Rader Peter W F Wilson Yan V SunJ Michael GazianoThemistocles L Assimesnull null

Published in: Circulation. Genomic and precision medicine (2022)

The risk associated with carrying an FH variant cannot be fully captured by the LDL-C data available in the electronic health record, even when considering multiple LDL-C measurements spanning more than a decade.

Keyphrases

electronic health record
low density lipoprotein
coronary artery disease
clinical decision support
adverse drug
percutaneous coronary intervention
cardiovascular events
cross sectional
coronary artery bypass grafting
heart failure
cardiovascular disease
machine learning
atrial fibrillation
data analysis