Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma.

Kazushige KoikeHironari DehariKazuhiro OgiShota ShimizuKoyo NishiyamaTomoko SonodaTakanori SasakiTakashi SasayaKei TsuchihashiTadashi HasegawaToshihiko TorigoeHiroyoshi HiratsukaAkihiro Miyazaki

Published in: PloS one (2020)

The presence of FoxP3⁺ T-cells in the parenchyma of the invasive front may be a useful prognostic factor. Our results indicate that FoxP3⁺ T-cells may exert site-specific anti-tumor effects but may not play an immunosuppressive role in OSCC. In addition, our results suggest that CTLA-4+ cells suppress the function of FoxP3+ T-cells and promote anti-tumor immunity in OSCC.

Keyphrases

regulatory t cells
prognostic factors
dendritic cells
induced apoptosis
poor prognosis
cell cycle arrest
oxidative stress
immune response
cell death
binding protein
endoplasmic reticulum stress
cell proliferation