Evaluation of CD39, CD73, HIF-1α, and their related miRNAs expression in decidua of preeclampsia cases compared to healthy pregnant women.
Yousef YousefzadehMohammad Sadegh Soltani-ZangbarLadan KalafiAli TarbiatSima Shahmohammadi FaridLeili Aghebati-MalekiForough ParhizkarShahla DanaiiSimin TaghaviFarhad Jadidi-NiaraghHossein Samadi KafilAta MahmoodpoorJavad Ahmadian HerisMohammad Hojjat-FarsangiMehdi YousefiPublished in: Molecular biology reports (2022)
In conclusion, our results showed that aberrant expression of molecules that are involved in ATP catabolism and the hypoxic conditions is observed in PE cases and involved in their hypertension and inflammation could be served as PE prognosis by more confirming in comprehensive future studies. miR-206 and miR-30a play a role by regulating CD39 and CD73 as molecules that are involved in ATP catabolism as well as regulating the production of IGF-1 in the process of hypertension, which is the main feature in patients with preeclampsia. On the other hand, decreased level of miR-18a lead to upregulation of HIF-1a, and the consequence condition of hypoxia increases hypertension and inflammation in these patients.
Keyphrases
- poor prognosis
- long non coding rna
- cell proliferation
- blood pressure
- pregnant women
- long noncoding rna
- end stage renal disease
- oxidative stress
- endothelial cells
- early onset
- ejection fraction
- binding protein
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- prognostic factors
- machine learning
- current status
- nk cells
- patient reported outcomes
- patient reported
- drug induced
- growth hormone