Translating transcription: proteomics in chronic rhinosinusitis with nasal polyps reveals significant discordance with messenger RNA expression.

Alan D WorkmanAngela L NoceraSarina K MuellerHasan H OtuTowia A LibermannBenjamin S Bleier

Published in: International forum of allergy & rhinology (2019)

Proteomic analysis in CRSwNP has revealed novel disease-associated proteins and pathways, yet correlates poorly with transcriptomic data. The increasing availability of proteomic arrays opens the door to new potential explanatory mechanisms in CRSwNP and suggests that mRNA based studies should be validated with protein analysis.

Keyphrases

chronic rhinosinusitis
binding protein
single cell
poor prognosis
label free
mass spectrometry
big data
transcription factor
amino acid
machine learning
long non coding rna
risk assessment
human health
climate change
small molecule
case control
nucleic acid
data analysis