Effect of type 1 diabetes during pregnancy and lactation on neonatal hypoxia-ischemia injury and apoptotic gene expression.

Zahra AzadbakhtHamed Fanaei Mansour KarajibaniFarzaneh Montazerifar

Published in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2023)

According to the results, type 1 diabetes during pregnancy and lactation increased the destructive effects of HI injury in pups. It also decreased the expression of the anti-apoptotic Bcl-2 and increased the expression BAX apoptosis factor gene in pups.

Keyphrases

type diabetes
cell death
gene expression
poor prognosis
glycemic control
human milk
cardiovascular disease
dairy cows
oxidative stress
cell cycle arrest
binding protein
endothelial cells
insulin resistance
anti inflammatory
copy number
genome wide identification
metabolic syndrome
induced apoptosis
preterm birth