Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 via miR-411-5p.

Jiancheng Pan Zihao Liu Zhizhao Yang Enli Liang Cheng Fang Dingrong Zhang Xiaodong Zhou Yuanjie Niu Zhong Cheng Xin Yegang Chen Qiliang Cai

Published in: The world journal of men's health (2021)

Circ_0001686 can reduce miR-411-5p to increase the expression of SMAD3/TGFBR2, which consequently promotes the proliferation, invasion, and migration of PCa cells.

Keyphrases

prostate cancer
epithelial mesenchymal transition
transforming growth factor
induced apoptosis
poor prognosis
signaling pathway
radical prostatectomy
cell cycle arrest
cell migration
endoplasmic reticulum stress
cell death
cell proliferation