Clinical and histopathological features of chronic hepatitis B virus infected patients with high HBV-DNA viral load and normal alanine aminotransferase level: A multicentre-based study in China.

Yu-Feng XingDa-Qiao ZhouJing-Song HeChun-Shan WeiWei-Chao ZhongZhi-Yi HanDe-Ti PengMu-Min ShaoTung-Ting ShamDaniel Kam-Wah MokChi-On ChanGuang-Dong Tong

Published in: PloS one (2018)

Our results showed that histological changes in liver tissues were observed in a significant proportion of patients with persistently normal alanine aminotransferase level. According to the data evaluation results, liver biopsy is advisable for HBeAg-positive chronic hepatitis B infected patients aged older than 40 and high HBV-DNA viral load in China.

Keyphrases

hepatitis b virus
liver failure
circulating tumor
cell free
single molecule
clinical trial
gene expression
physical activity
electronic health record
study protocol
randomized controlled trial
big data
middle aged
ultrasound guided
nucleic acid
double blind
community dwelling