Free fatty acid receptor 4 in cardiac myocytes ameliorates ischemic cardiomyopathy.
Michael J ZhangSergey KarachenetsDylan J GybergSara PucciniChastity L HealySteven C WuGregory C ShearerTimothy D O'ConnellPublished in: bioRxiv : the preprint server for biology (2024)
Our results demonstrate that Ffar4 in cardiac myocytes attenuates systolic dysfunction post-I/R, potentially by attenuating oxidative stress, preserving mitochondrial function, and modulation of cGMP signaling.