Overexpression of Mothers Against Decapentaplegic Homolog 7 Activates the Yes-Associated Protein/NOTCH Cascade and Promotes Liver Carcinogenesis in Mice and Humans.

Haichuan WangXinhua SongHaotian LiaoPan WangYi ZhangLi CheJie ZhangYi ZhouAntonio CiglianoCindy AmentDaphne SupervilleSilvia RibbackMelissa ReevesGiovanni M PesBinyong LiangHong WuMatthias EvertDiego F CalvisiYong ZengXin Chen

Published in: Hepatology (Baltimore, Md.) (2021)

The present data indicate that SMAD7 contributes to liver carcinogenesis by activating the YAP/NOTCH signaling cascade and inducing a cholangiocellular and EMT signature.

Keyphrases

epithelial mesenchymal transition
cell proliferation
signaling pathway
electronic health record
high fat diet induced
transcription factor
skeletal muscle
deep learning