Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU)-Protocol for a randomised clinical trial comparing a lower vs a higher oxygenation target in adults with acute hypoxaemic respiratory failure.

Olav Lilleholt Schjørring Anders Perner Jorn Wetterslev Theis Lange Frederik Keus Jon Henrik LaakeMarjatta OkkonenMartin SiegemundMatt P G MorganKatrin M ThormarBodil Steen Rasmussennull null

Published in: Acta anaesthesiologica Scandinavica (2019)

The HOT-ICU trial will test the hypothesis that a lower oxygenation target reduces 90-day mortality compared with a higher oxygenation target in adult ICU patients with acute hypoxaemic respiratory failure.

Keyphrases

respiratory failure
mechanical ventilation
clinical trial
intensive care unit
acute respiratory distress syndrome
extracorporeal membrane oxygenation
blood flow
study protocol
open label
phase ii
double blind
phase iii
randomized controlled trial
risk factors
placebo controlled
hepatitis b virus