C2orf40 inhibits hepatocellular carcinoma through interaction with UBR5.

Yue WuQin XiangXiaoqin LvXia XiangZhihao FengShaorong TianJun TangTing-Xiu XiangJianping Gong

Published in: Journal of gastroenterology and hepatology (2021)

Low expression levels of C2orf40 are related to the hypermethylation of its promoter. C2orf40 can inhibit HCC through UBR5-dependent or p53-independent mechanisms. C2orf40 may be a diagnostic biomarker and a potential therapeutic target in HCC.

Keyphrases

poor prognosis
dna methylation
gene expression
transcription factor