PSCA expression is associated with favorable tumor features and reduced PSA recurrence in operated prostate cancer.

Marie-Christine HeinrichCosima GöbelMartina KluthChristian BernreutherCharlotte SauerCornelia SchroederChristina Möller-KoopClaudia Hube-MaggPatrick LebokEike BurandtGuido SauterRonald SimonHartwig HulandMarkus GraefenHans HeinzerThorsten SchlommAsmus Heumann

Published in: BMC cancer (2018)

The absence of statistical relationship to TMPRSS2:ERG fusion status, chromosomal deletion or high tumor cell proliferation argues against a major role of PSCA for regulation of cell cycle or genomic integrity. PSCA expression is linked to favorable prognosis. PSCA measurement is a candidate for inclusion in multi-parametric prognostic prostate cancer tests.

Keyphrases

prostate cancer
cell cycle
cell proliferation
radical prostatectomy
poor prognosis
copy number
binding protein
long non coding rna
gene expression
pi k akt
signaling pathway
dna methylation