Home Treatment of Older People with Symptomatic SARS-CoV-2 Infection (COVID-19): A structured Summary of a Study Protocol for a Multi-Arm Multi-Stage (MAMS) Randomized Trial to Evaluate the Efficacy and Tolerability of Several Experimental Treatments to Reduce the Risk of Hospitalisation or Death in outpatients aged 65 years or older (COVERAGE trial).
Alexandre DuvignaudEdouard LhommeThierry PistoneRacha OnaisiRémi SittaValérie JournotDuc NguyenNathan Peiffer-SmadjaAntoine CrémerStéphane BouchetThomas DarnaudDelphine PoitrenaudLionel PirothChristine BinquetJean-François MichelBenjamin LefèvreDavid LebeauxJosselin LebelJulie DupouyCaroline RoussillonAnne GimbertLinda WittkopRodolphe ThiébautJoanna Orne-GliemannJean-Philippe JosephLaura RichertXavier AnglaretDenis Malvynull nullPublished in: Trials (2020)
The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest of expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2).