Latest advances in multimodality imaging of aortic stenosis.
Evangelos TzolosJacek KwiecinskiDaniel S BermanPiotr J SlomkaDavid E NewbyMarc DweckPublished in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine (2021)
Aortic stenosis is a common condition associated with major morbidity, mortality and healthcare costs. Despite this, we currently lack any effective medical therapies that can treat or prevent disease development or progression. Modern advances in echocardiography and computed tomography (CT) have helped improve the assessment of aortic stenosis severity and monitoring of disease progression, whilst cardiac magnetic resonance (CMR) imaging informs on myocardial health and the development of fibrosis. In a series of recent studies, 18F- sodium fluoride positron emission tomography and computed tomography has been shown to assess valvular disease activity and progression, providing mechanistic insights that can inform potential novel therapeutic approaches. This review will examine the latest advances in the imaging of aortic stenosis and bioprosthetic valve degeneration and explore how these techniques can assist patient management and potentially accelerate novel therapeutic developments.
Keyphrases
- aortic stenosis
- computed tomography
- positron emission tomography
- aortic valve
- left ventricular
- transcatheter aortic valve replacement
- aortic valve replacement
- ejection fraction
- transcatheter aortic valve implantation
- healthcare
- disease activity
- magnetic resonance
- high resolution
- mitral valve
- dual energy
- coronary artery disease
- contrast enhanced
- systemic lupus erythematosus
- magnetic resonance imaging
- rheumatoid arthritis
- heart failure
- public health
- pet ct
- health information
- cardiovascular events
- image quality
- mental health
- pet imaging
- atrial fibrillation
- fluorescence imaging
- ankylosing spondylitis
- rheumatoid arthritis patients
- human health
- cardiovascular disease
- type diabetes
- liver fibrosis
- photodynamic therapy
- risk assessment
- social media