An Initial miRNA Profile of Persons With Persisting Neurobehavioral Impairments and States of Disordered Consciousness After Severe Traumatic Brain Injury.
Michael J ZillioxEileen M FoeckingGina R KuffelMark ConneelyKaren L SabanAmy A HerroldSandra L KletzelJay R RadkeElyse WalshAnn GuernonAriana PapeDavid L RipleyVijaya PatilMarilyn S PachecoJoshua M RosenowRuna BhaumikDulal BhaumikTheresa L Bender PapePublished in: The Journal of head trauma rehabilitation (2022)
Patients remaining in states of DoC an average of 1.5 years after TBI showed a different and reproducible pattern of miRNA expression relative to age/gender-matched neurotypical controls. The phenotypes, defined by miRNA profiles relative to persisting neurobehavioral impairments, provide the basis for future research to determine the miRNA profiles differentiating states of DoC and the basis for future research using miRNA to detect treatment effects, predict treatment responsiveness, and developing targeted interventions. If future research confirms and advances reported findings, then miRNA profiles will provide the foundation for patient-centric DoC neurorehabilitation.
Keyphrases
- severe traumatic brain injury
- current status
- traumatic brain injury
- end stage renal disease
- ejection fraction
- newly diagnosed
- poor prognosis
- prognostic factors
- magnetic resonance imaging
- mental health
- computed tomography
- peritoneal dialysis
- magnetic resonance
- combination therapy
- long non coding rna
- patient reported outcomes
- drug delivery