The effect of Ccnb1ip1 insulator on monoclonal antibody expression in Chinese hamster ovary cells.

Azam RahimpourEs'hagh PourmalekiForough ShamsZahra PayandehNavid PourzardoshtMojtaba DidehdarMilad Gholami

Published in: Molecular biology reports (2022)

More studies are needed to fully elucidate the effects of Ccnb1ip1 gene insulator on recombinant therapeutic protein expression in mammalian cells. The combination of this element with other chromatin-modifying elements might improve its augmentation effect which could pave the way for efficient and cost-effective production of therapeutic drugs.

Keyphrases

monoclonal antibody
induced apoptosis
genome wide
poor prognosis
cell cycle arrest
gene expression
transcription factor
copy number
dna methylation
signaling pathway
binding protein
case control
oxidative stress
soft tissue
drug induced
cell proliferation