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Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup.

Ione O C WoollacottJennifer M NicholasAmanda HeslegraveCarolin HellerMartha S FoianiKatrina M DickLucy L RussellRoss W PatersonAshvini KeshavanNick C FoxJason D WarrenJonathan M SchottHenrik ZetterbergJonathan Daniel Rohrer
Published in: Alzheimer's research & therapy (2018)
Although CSF sTREM2 levels are not raised in FTD overall or in a particular clinical subtype of FTD, levels are raised in familial FTD associated with GRN mutations and in FTD syndromes due to AD pathology. Because CSF sTREM2 levels correlate with a marker of neuronal injury (T-tau), sTREM2 should be explored as a biomarker of disease intensity in future longitudinal studies of FTD.
Keyphrases
  • cerebrospinal fluid
  • clinical trial
  • early onset
  • dna methylation
  • cross sectional
  • current status
  • copy number
  • subarachnoid hemorrhage
  • blood brain barrier
  • study protocol
  • open label