Cerebrospinal fluid soluble TREM2 levels in frontotemporal dementia differ by genetic and pathological subgroup.
Ione O C WoollacottJennifer M NicholasAmanda HeslegraveCarolin HellerMartha S FoianiKatrina M DickLucy L RussellRoss W PatersonAshvini KeshavanNick C FoxJason D WarrenJonathan M SchottHenrik ZetterbergJonathan Daniel RohrerPublished in: Alzheimer's research & therapy (2018)
Although CSF sTREM2 levels are not raised in FTD overall or in a particular clinical subtype of FTD, levels are raised in familial FTD associated with GRN mutations and in FTD syndromes due to AD pathology. Because CSF sTREM2 levels correlate with a marker of neuronal injury (T-tau), sTREM2 should be explored as a biomarker of disease intensity in future longitudinal studies of FTD.