Association of Brain Age, Lesion Volume, and Functional Outcome in Patients With Stroke.
Sook-Lei LiewNicolas SchweighoferJames H ColeArtemis Zavaliangos-PetropuluBethany P LoLaura K M HanTim HahnLianne SchmaalMiranda R DonnellyJessica N JeongZhizhuo WangAisha AbdullahJun H KimAlexandre M HuttonGiuseppe BarisanoMichael R BorichLara A BoydAmy BrodtmannCathrin M BuetefischWinston D ByblowJessica M CassidyCharalambos C CharalambousValentina CiulloAdriana Bastos ConfortoRosalia Dacosta-AguayoJulie A DiCarloMartin DominAdrienne N DulaMohamed Salah KhlifWuwei FengFatemeh GeranmayehChris M GregoryColleen A HanlonKathryn S HaywardJess A HolguinBrenton G HordacreNeda JahanshadSteven A KautzMohamed Salah KhlifHosung KimAmy F KuceyeskiDavid J LinJingchun LiuMartin LotzeBradley J MacIntoshJohn L MargetisMaria MataroFeroze B MohamedEmily R OlafsonGilsoon ParkFabrizio PirasKate Pirog RevillPamela S RobertsAndrew D RobertsonNerses SanossianHeidi M SchambraNa Jin SeoSurjo R SoekadarGianfranco SpallettaCathy M StinearMyriam TagaWai Kwong TangGreg T ThielmanDaniela VecchioNick S WardLars Tjelta WestlyeCarolee J WinsteinGeorge F WittenbergSteven L WolfKristin A WongChunshui YuSteven C CramerPaul M ThompsonPublished in: Neurology (2023)
We provide evidence that younger brain age is associated with superior post-stroke outcomes and modifies the impact of focal damage. The inclusion of imaging-based assessments of brain age and brain resilience may improve the prediction of post-stroke outcomes compared to focal injury measures alone, opening new possibilities for potential therapeutic targets.