UpStreAm doxycycline in ST-eLeVation myocArdial infarction - targetinG infarct hEaling and ModulatIon (SALVAGE-MI trial).
Samer NoamanChristopher NeilJessica O'BrienMichael FrenneauxJames HareBing WangTsin Yee TaiJames TheuerleJames A ShawDion StubJason BloomAntony WaltonStephen J DuffyKarl-Heinz PeterNicholas CoxDavid M KayeAndrew TaylorWilliam ChanPublished in: European heart journal. Acute cardiovascular care (2022)
Doxycycline prior to PPCI neither reduced IS acutely or at 6 months nor attenuated adverse LV remodeling. These data raise safety concerns regarding doxycycline use in STEMI for infarct modulation and healing.
Keyphrases
- st elevation myocardial infarction
- percutaneous coronary intervention
- acute myocardial infarction
- st segment elevation myocardial infarction
- acute coronary syndrome
- coronary artery disease
- study protocol
- clinical trial
- electronic health record
- phase iii
- big data
- phase ii
- randomized controlled trial
- emergency department
- machine learning
- drug delivery
- adverse drug
- data analysis
- artificial intelligence
- open label
- deep learning
- placebo controlled