Production and purification of chimeric HBc virus-like particles carrying influenza virus LAH domain as vaccine candidates.

Andris KazaksI-Na LuSophie FarinelleAlex RamirezVincenzo CrescenteBenjamin BlahaOlotu OgonahTarit MukhopadhyayMapi Perez de ObanosAlejandro KrimerInara AkopjanaJanis BogansVelta OseAnna KirsteinaTatjana KazakaNicola J StonehouseDavid J RowlandsClaude P MullerKaspars TarsWilliam M Rosenberg

Published in: BMC biotechnology (2017)

Our results indicate that the tandem core technology is a useful tool for incorporation of highly hydrophobic LAH domain into HBc VLPs. Chimeric VLPs can be successfully produced in bioreactor using yeast expression system. Immunologic data indicate that HBc VLPs carrying the LAH antigen represent a promising universal influenza vaccine component.

Keyphrases

cell therapy
poor prognosis
electronic health record
wastewater treatment
big data
stem cells
ionic liquid
mesenchymal stem cells
binding protein
long non coding rna
data analysis
cell wall
aqueous solution