Effects of urolithins on obesity-associated gut dysbiosis in rats fed on a high-fat diet.
Abdulrasheed O AbdulrahmanMohammed Yahya AlzubaidiMuhammad Shahid NadeemJalaluddin Awlia KhanIrfan A RatherMohammad Imran KhanPublished in: International journal of food sciences and nutrition (2021)
Obesity is a global health concern associated with the dysbiosis of intestinal microbial composition. In this study, we investigated the potentials of urolithin A (Uro-A) and urolithin B (Uro-B), two gut microbiota-derived metabolites of ellagitannins, in reducing body weight gain through the modulation of the gut microbiota. We established a high-fat diet (HFD)-induced obesity model in rats that were later administered with either 2.5 mg/kg of Uro-A or Uro-B. Serum biochemical parameters were quantified, and changes in the composition of the gut microbial community were analysed using 16S rDNA gene sequencing. Our results showed that the urolithins significantly decreased the body weight in HFD-fed rats and restored serum lipid profile. The taxonomic analysis showed that both Uro-A and Uro-modulated gut microbes related to body weight, dysfunctional lipid metabolism and inflammation. Overall, our results suggest that Uro-A and Uro-B possess anti-obesity properties, which may be related to the modulation of the gut microbial composition.
Keyphrases
- high fat diet
- insulin resistance
- weight gain
- microbial community
- body weight
- adipose tissue
- metabolic syndrome
- weight loss
- high fat diet induced
- type diabetes
- skeletal muscle
- body mass index
- birth weight
- global health
- public health
- antibiotic resistance genes
- ms ms
- physical activity
- mass spectrometry
- wastewater treatment
- dna methylation
- data analysis
- high glucose