Tamoxifen Response at Single Cell Resolution in Estrogen Receptor-Positive Primary Human Breast Tumors.

Hyunsoo Kim Austin A Whitman Kamila Wisniewska Rasha T Kakati Susana García-Recio Benjamin C Calhoun Hector L Franco Charles M Perou Philip M Spanheimer

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

This novel ex vivo model system now provides a foundation to define responsive and resistant sub-populations within heterogeneous human tumors, which can be used to develop precise single cell-based predictors of response to therapy and to identify genes and pathways driving therapeutic resistance.

Keyphrases

estrogen receptor
single cell
endothelial cells
rna seq
induced pluripotent stem cells
pluripotent stem cells
high throughput
genome wide
gene expression
cancer therapy
drug delivery
transcription factor
single molecule
cell therapy
genetic diversity
bioinformatics analysis