Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males.
Laura A B WilsonSusanne R K ZajitschekMalgorzata LagiszJeremy C MasonHamed HaselimashhadiShinichi NakagawaPublished in: Nature communications (2022)
Sex differences in the lifetime risk and expression of disease are well-known. Preclinical research targeted at improving treatment, increasing health span, and reducing the financial burden of health care, has mostly been conducted on male animals and cells. The extent to which sex differences in phenotypic traits are explained by sex differences in body weight remains unclear. We quantify sex differences in the allometric relationship between trait value and body weight for 363 phenotypic traits in male and female mice, recorded in >2 million measurements from the International Mouse Phenotyping Consortium. We find sex differences in allometric parameters (slope, intercept, residual SD) are common (73% traits). Body weight differences do not explain all sex differences in trait values but scaling by weight may be useful for some traits. Our results show sex differences in phenotypic traits are trait-specific, promoting case-specific approaches to drug dosage scaled by body weight in mice.
Keyphrases
- body weight
- genome wide
- healthcare
- dna methylation
- high fat diet induced
- type diabetes
- induced apoptosis
- poor prognosis
- public health
- stem cells
- emergency department
- mental health
- body mass index
- gene expression
- climate change
- drug delivery
- risk assessment
- insulin resistance
- binding protein
- cancer therapy
- cell death
- long non coding rna
- health insurance
- single cell
- endoplasmic reticulum stress
- health promotion