Low CYP24A1 mRNA expression and its role in prognosis of breast cancer.
Hongqiao CaiYan JiaoYanqing LiZhaoying YangMiao HeYahui LiuPublished in: Scientific reports (2019)
Breast cancer is the most common malignant cancer in women. CYP24A1 expression regulates cellular response to vitamin D, which has antitumor effects against breast cancer. This study aimed to identify the correlation between CYP24A1 mRNA expression and prognosis of breast cancer. This study enrolled 1102 patients, including 1090 females and 12 males, from TCGA-BRCA cohort. The Cancer Genome Atlas database was used to study CYP24A1 mRNA expression in breast cancer, and Chi-squared tests were performed to test the correlation between clinical features and CYP24A1 expression. The prognostic value of CYP24A1 in breast cancer was assessed using Kaplan-Meier curves and Cox analysis. Low CYP24A1 expression was associated with age, molecular subtype, ER, PR, HER2, menopause status, N classification, vital status, overall survial and relapse-free survival. CYP24A1 presented a moderate diagnostic ability in breast cancer. Furthermore, low CYP24A1 expression was correlated with poor prognosis. CYP24A1 was an independent risk factor for breast cancer. CYP24A1 plays an important role in prognosis of breast cancer. CYP24A1 has the potential to be a biomarker, especially in predicting prognosis.
Keyphrases
- poor prognosis
- long non coding rna
- breast cancer risk
- machine learning
- gene expression
- emergency department
- squamous cell carcinoma
- newly diagnosed
- binding protein
- end stage renal disease
- single cell
- skeletal muscle
- climate change
- young adults
- insulin resistance
- human health
- patient reported outcomes
- endoplasmic reticulum