A Genome-Wide Association Study of Nausea Incidence in Varenicline-Treated Cigarette Smokers.
Meghan J ChenowethCaryn LermanJoanne KnightRachel F TyndalePublished in: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco (2021)
Varenicline-associated nausea reduces adherence and limits cessation success. Previous candidate gene association studies showed genetic factors influence nausea on varenicline. This pilot genome-wide investigation of nausea, the most common side effect associated with varenicline treatment and an important cause of treatment discontinuation, suggests the potential involvement of common variation in the SLCO3A1 drug transporter gene.
Keyphrases
- smoking cessation
- genome wide
- replacement therapy
- chemotherapy induced
- copy number
- genome wide association study
- dna methylation
- randomized controlled trial
- gene expression
- adipose tissue
- risk factors
- combination therapy
- study protocol
- clinical trial
- skeletal muscle
- insulin resistance
- metabolic syndrome
- climate change
- case control