Integrative prognostic analysis of tumor-infiltrating lymphocytes, CD8, CD20, programmed cell death-ligand 1, and tertiary lymphoid structures in patients with early-stage triple-negative breast cancer who did not receive adjuvant chemotherapy.
Shu YazakiTatsunori ShimoiMasayuki YoshidaHitomi Sumiyoshi-OkumaMotoko ArakakiAyumi SaitoShosuke KitaKasumi YamamotoYuki KojimaTadaaki NishikawaMaki TaniokaKazuki SudoEmi NoguchiTakeshi MurataSho ShiinoShin TakayamaAkihiko SutoYuichiro OheYasuhiro FujiwaraKan YonemoriPublished in: Breast cancer research and treatment (2022)
CD8 and PD-L1 levels add prognostic information beyond TILs for early-stage TNBC not receiving perioperative chemotherapy. CD8-positive T cells and PD-L1 may be useful for prognostic stratification and in designing future clinical trials of TNBC.