The Effectiveness of Leukocyte-Poor Platelet-Rich Plasma Injections for Symptomatic Mild to Moderate Osteoarthritis of the Knee With Joint Effusion or Bone Marrow Lesions in a Japanese Population: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Tomokazu YoshiokaNorihito AraiHisashi SugayaYu TaniguchiAkihiro KanamoriMasahiko GoshoKosuke OkunoNaoya KikuchiKojiro HyodoKatsuya AotoMasashi YamazakiPublished in: The American journal of sports medicine (2024)
In Japanese patients with knee OA, 3 intra-articular LP-PRP injections led to clinical improvements at 24-week follow-up and significant functional improvements and pain relief after 24 weeks.
Keyphrases
- platelet rich plasma
- placebo controlled
- double blind
- knee osteoarthritis
- clinical trial
- bone marrow
- total knee arthroplasty
- phase ii
- phase iii
- study protocol
- phase ii study
- chronic pain
- randomized controlled trial
- mesenchymal stem cells
- systematic review
- neuropathic pain
- anterior cruciate ligament
- pain management
- anterior cruciate ligament reconstruction
- peripheral blood
- squamous cell carcinoma
- spinal cord injury
- spinal cord
- radiation therapy
- preterm birth
- light emitting