Testosterone supplementation increases red blood cell susceptibility to oxidative stress, decreases membrane deformability, and decreases survival after cold storage and transfusion.

Johnson Q Tran Rachael P Jackman Marcus O MuenchKelsey HazeghScott-Wesley BeanKimberly A ThomasFang FangGrier PageKim O'ConnorNareg H RoubinianBradley D AnawaltTamir Kanias

Published in: Transfusion (2024)

TT is associated with altered RBC characteristics and transfusion effectiveness. These results suggest that clinical utilization of TT RBCs may be less effective in recipients who benefit from longer RBC survival, such as chronically transfused patients.

Keyphrases

red blood cell
oxidative stress
end stage renal disease
cardiac surgery
chronic kidney disease
ejection fraction
newly diagnosed
randomized controlled trial
systematic review
acute kidney injury
patient reported outcomes
induced apoptosis
patient reported
endoplasmic reticulum stress