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miR-657 Targets SRCIN1 via the Slug Pathway to Promote NSCLC Tumor Growth and EMT Induction.

Yingqian ZhangJiao YuanMengfei GuoRun XiangXiang WangTianpeng XieXiang ZhuangQiang LiQi Lai
Published in: Disease markers (2022)
The obtained findings illuminate that miR-657 can promote the growth of tumors and the induction of the EMT in NSCLC cells by targeting SRCIN1 expression and modulating Slug pathway activation, highlighting this pathway as a promising therapeutic target in cases suffering from NSCLC.
Keyphrases
  • epithelial mesenchymal transition
  • small cell lung cancer
  • cell proliferation
  • long non coding rna
  • advanced non small cell lung cancer
  • poor prognosis
  • long noncoding rna
  • signaling pathway
  • brain metastases