Relay Copper-Catalyzed Synthesis of Imidazo[1,5- a ]pyridine Scaffolds from Phenylalanine and Halohydrocarbon.

An efficient and straightforward strategy to synthesize imidazo[1,5- a ]pyridine compounds from phenylalanine and halohydrocarbon has been successfully developed. The protocol features a relay copper-catalyzed reaction involving intermolecular C-O coupling and intramolecular C-N cyclization, providing an approach to access a diverse range of imidazo[1,5- a ]pyridine derivatives with unique aza quaternary carbon centers.